Detail information to gene: TP53
Gene symbol	TP53
Gene description	tumor protein p53
Gene aliases	FLJ92943 LFS1 p53 TRP53
Species	Human
Chromosomal location	17p13.1
Entrez ID	7157
Ensembl ID	ENSG00000141510
Molecular association	PSC
Literature	PubMed: 8801209 PubMed: 10735605 PubMed: 11168786
Further molecular associations	NASH HCC CCC
Functional associations to gene: TP53
RNA Seq Atlas
LoMA associations	NASH HCC PSC CCC
CellMinerHCC data
GeneOntology	protein import into nucleus, translocation DNA strand annealing activity in utero embryonic development transcription factor activity nuclease activity copper ion binding protein binding ATP binding insoluble fraction nucleus nucleoplasm replication fork nucleolus cytoplasm mitochondrion cytosol base-excision repair nucleotide-excision repair transcription regulation of transcription, DNA-dependent protein complex assembly apoptosis induction of apoptosis response to DNA damage stimulus cell cycle cell cycle arrest multicellular organismal development cell aging protein localization negative regulation of DNA replication zinc ion binding caspase activation via cytochrome c response to UV embryonic development ending in birth or egg hatching response to X-ray nuclear matrix enzyme binding cell differentiation negative regulation of cell growth G1 DNA damage checkpoint regulation of cell proliferation DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis negative regulation of apoptosis positive regulation of transcription positive regulation of transcription from RNA polymerase II promoter metal ion binding regulation of mitochondrial membrane permeability protein heterodimerization activity protein N-terminus binding negative regulation of fibroblast proliferation negative regulation of helicase activity protein tetramerization
Associated Pathways	MAPK signaling pathway Cell cycle p53 signaling pathway Apoptosis Wnt signaling pathway Amyotrophic lateral sclerosis (ALS) Huntington's disease Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer