Detail information to gene: TNF
Gene symbol	TNF
Gene description	tumor necrosis factor (TNF superfamily, member 2)
Gene aliases	DIF TNFA TNF-alpha TNFSF2
Species	Human
Chromosomal location	6p21.3
Entrez ID	7124
Ensembl ID	ENSG00000204490
Molecular association	PSC
Literature	PubMed: 11313318 PubMed: 11454808
Further molecular associations	NASH AIH Liver_Fibrosis CCC
Functional associations to gene: TNF
RNA Seq Atlas
LoMA associations	NASH PSC AIH Liver_Fibrosis CCC
CellMinerHCC data
GeneOntology	protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter regulation of protein amino acid phosphorylation cytokine activity tumor necrosis factor receptor binding protein binding extracellular space soluble fraction plasma membrane glucose metabolic process regulation of transcription, DNA-dependent apoptosis anti-apoptosis defense response humoral immune response leukocyte adhesion signal transduction multicellular organismal development induction of apoptosis by extracellular signals induction of apoptosis via death domain receptors response to virus organ morphogenesis integral to membrane osteoclast differentiation regulation of cell proliferation defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB cascade cellular extravasation regulation of osteoclast differentiation positive regulation of transcription positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron negative regulation of glucose import positive regulation of JNK cascade leukocyte migration regulation of immunoglobulin secretion positive regulation of NF-kappaB transcription factor activity
Associated Pathways	MAPK signaling pathway Cytokine-cytokine receptor interaction Apoptosis TGF-beta signaling pathway Toll-like receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Fc epsilon RI signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Type I diabetes mellitus Asthma Allograft rejection Graft-versus-host disease